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A Raju, Hyderabad June 18 , 2017
A team of scientists and researchers from Council of Scientific and Industrial Research-Indian Institute of Chemical Technology (CSIR-IICT) at Hyderabad have embarked on developing a new drug to regulate glucose effectively and help the diabetic patients from the hassles of gulping regular pills.

According to Dr S Chandrasekhar, Director of CSIR-IICT, a team of scientists from IICT are working on a new structure to bring out a better diabetic drug for the last eight years. As part of their research the scientists have found promising results so far and have completed all the pre-requirements for phase I trials.

Dr Saibal Das, senior scientist, who is working on the development of the new drug, said that they would soon start the structure activity studies. “Presently, patients pop a pill every day. To overcome these medical inconveniences for the patients, we are working towards making a potential candidate that can work for a week. We are developing inhibitors that will sit on PPP-4 compound protein and regulate glucose level,” said Dr Saibal Das.

The scientists explained that DPP-4 inhibitors work by blocking the action of DPP-4, an enzyme which destroys incretin. Incretins help the body produce more insulin. IICT scientists have been working with biologists from different countries towards increasing the half life of the compound. This means the time taken by the drug to be active in the body.

The researchers revealed that results so far have been promising. The timeline for a drug discovery is a minimum of 15 years. IICT scientists have passed the half-way stage. Dr Chandrasekhar says, “We are forging ahead with several collaborations with institutes from across the world and the industry interface too is looking up. This new structure could be a boon for diabetic patients.”

 He further said, “The Natural Product Division of IICT takes inspiration from natural products and comes out with new structures. The impetus is to expand ties with institutes across the world for mutual benefit in medicinal as well as chemical technology.”

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